Omoni Oboli was born 22 April 1978 in Benin City in Edo State, Nigeria. She is a descent of Mosogar in Delta State.
Oboli studied Foreign Languages at the University of Benin majoring in French. In 1996, while still at the university, she featured in her first films. Shen then took a 10 year break, got married, and returned to the screen in 2009 with the movie Entanglement. 2010 saw Omoni Oboli’s big break into Nollywood featuring in the award-winning film The Figurine.